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CJC 1295 Comprehensive Guide – Side Effects, Benefits, Usage

CJC 1295 Benefits, Side Effects, Effective Use

What is CJC 1295?

CJC 1295 is a synthetic peptide analogue of Growth Hormone Releasing Hormone (GHRH) – a hormone that stimulates GH production through a pulsating fashion.

CJC 1295 causes significant increases in GH and IGF-1 levels and increases lean muscle mass, burns fat, and improves your general performance and quality of life in many ways. 

There are two types of CJC 1295 – CJC 1295 with DAC, and CJC 1295 without DAC.

DAC stands for “Drug Affinity Complex”, and it’s an addition that extends the half-life of CJC 1295 making it more effective and convenient for performance-enhancing purposes.

CJC 1295 and Ipamorelin are completely different drugs. They are often taken together to create synergy because they both boost GH & IGF-1 but through different mechanisms of action.

In this article you will learn everything there is to know about CJC 1295 based on the latest academic data, and the careful analysis of hundreds upon hundreds of anecdotal reports and experiences online.


The benefits of CJC 1295 are many and range from general performance enhancement in terms of increased muscle growth, performance, strength, and fat loss, to dramatically better sleep, better skin, hair, and overall quality of life.

It is not only a PED that can be useful for professional athletes, but also has traits that make it a great compound for improving longevity and health.

Here are the benefits of CJC 1295 in detail:

Lean Muscle Mass Increase [1][A]

CJC 1295 increases endogenous IGF-1, one of the most anabolic hormones in the body. IGF-1 significantly increases muscle protein synthesis (MPS) and is believed to contribute to muscular hyperplasia (the creation of new muscle cells).

Empirical information has confirmed this. CJC 1295 for prolonged periods of time can lead to a significant increase in lean muscle mass – provided that training variables are in place.

Fat Loss [2][A]

CJC 1295 can greatly aid fat loss by inducing lipolysis through endogenous GH secretion. Lipolysis is the reason why other peptides GH secretagogues and regular GH are so effective at burning fat.

So much so that scientists identified the amino sequence in the chain of GH, separated it, creating another extremely popular peptide called Frag 176 191.

Lipolysis is the process by which the body breaks down stored fat into fatty acids and glycerol, which can then be used as energy. It is a natural process that occurs when the body needs to access stored fat reserves to meet its energy demands. Lipolysis can be induced by various factors, including exercise, fasting, and certain hormones such as GH and adrenaline.

Anti-Ageing [3][A]

GH and IGF-1 have immensely important roles in improving longevity and youthfulness. They are proven to extend lifespan and improve quality of life drastically by improving mobility, bone strength, muscle mass, and regeneration.

Faster Healing [4][A]

Optimal levels of GH (and IGF-1 to an extent) are a huge contributor to healing injuries such as bone fractures, cuts, burns, and wounds.

GH is also responsible for keeping your joints lubricated. Both GH and IGF-1 also increase bone density and strength (as mentioned earlier).

By creating superphysiological levels of GH and IGF-1, CJC 1295 can speed up the healing of any injury and the muscular recovery time after exercise.

Cosmetic Benefits [5][A]

GH and IGF-1 increase collagen production. Collagen will give you that skin glow and elasticity that’s lost over the years, it will improve the strength of your hair, beard, and nails. With CJC 1295 these will grow faster, and stronger.

Other Benefits [6][A]

Apart from the aforementioned benefits, CJC 1295 will also:

  • Decrease inflammation
  • Improve memory
  • Fight neurodegeneration
  • Improve cardiovascular health
  • Improve immune response
  • Act as an antioxidant

Side Effects

The CJC 1295 side effects are very common for every compound that increases GH and IGF-1.

You can learn how to mitigate (almost) every of these side effects in my on-cycle therapy guide, though I will also leave summarized instructions below each section.

Unstable Blood Glucose Levels [7][A]

GH is known for increasing blood sugar levels. This is something you will have to keep an eye on while taking CJC 1295. Especially if your diet is heavy in carbs.

How to mitigate:

  • To fight this side effect I recommend taking 300mg of Berberine before every meal containing more than 50g of carbs while on CJC 1295.

Water Retention [A]

CJC 1295 will cause water retention which can potentially lead to high blood pressure and in some cases edema.

Water retention is very common with anything that increases GH.

How to mitigate:

  • To mitigate water retention from CJC 1295, lower your carb and sodium intake, and up your potassium intake by eating potassium-rich foods
  • Supplementing with Dandelion Root at 500mg/day or a natural diuretic blend will also help

Cancer (Growth Risk) [9][A]

CJC 1295 will accelerate the growth of existing cancer cells, as will anything that increases circulating levels of GH and IGF-1. This side effect can be potentially lethal for anyone that has cancer.

Other Side Effects [8][A]

Feeling lethargic, and feelings of numbness or tingling in extremities are common with anything that increases GH.

Having superphysiological levels of GH can also lead to the growth of hands, feet, nose, ears, and even organs.

How to mitigate:

  • Lethargy is typically resolved by simply lowering the dose
  • Tngling and numbness go away when measures against water retention are taken on

Dosing Protocol & Administration

CJC 1295 w/DAC has a half-life of 6-8 days. Because of its long half-life, it does not require daily injections like most peptides.

The optimal weekly dose for CJC 1295 is 2mg, which can be injected once or twice a week. If you want GH & IGF-1 levels to be more stable, then split the dose and inject twice a week. But personally, I find once a week to be enough.

Just like other peptides, CJC 1295 is administered through subcutaneous injections. The ideal place to inject is in the lower belly fat region. CJC 1295 can cause flu-like symptoms and dizziness a few hours after injection. So the best time to inject it is before bed, this way you sleep through these symptoms.

If you opt to fast in the morning, you will leverage and maximize the lipolysis caused by CJC 1295 if your goal is fat loss.

Combining CJC 1295 with Other Peptides

CJC 1295 is also a very good addition to MK 677 or Ipamorelin, as well as other GH secretagogues because it acts through a different pathway. Combining it with something else will lead to ridiculously high IGF-1 levels.

Cycle Length

If you are using CJC 1295 to:

  • gain muscle, burn fat, or heal an injury, I would not exceed 12 weeks. Always rest for 4-6 weeks (at least) before you cycle it again.
  • If you are using CJC 1295 for anti-aging, you can run it for long periods of time but only at a low dose.

There are anecdotal cases that have used this compound for 6 months + or more without any issues.


CJC 1295 is an incredible compound that increases endogenous GH and IGF-1 levels. It has many benefits both in terms of performance enhancement, cosmetics, and longevity, but it also comes with all the risks involved with elevated GH levels.

So, it should be used sparingly and always for a concrete purpose in mind.

Frequently Asked Questions

CJC 1295 doesn’t cause hot flushes. Users that experienced a hot flush from CJC 1295 probably took something entirely different thinking it was CJC 1295.

  • CJC 1295 is exceptional at treating heart disease by improving cardiovascular health through GH and IGF-1 secretion.

CJC 1295 should be taken at 2mg/week (injected once or twice) for a maximum of 12 weeks if your goal is fat/weight loss.


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