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Andarine (S4) Comprehensive Guide | Benefits, Side Effects, Use

A chemical formula for the SARM S-4 or Andarine

Andarine is a very popular SARM because of its effectiveness in building lean muscle in any setting. It is most often used for lean bulking or cutting because it doesn’t retain any water, just like Ostarine and Testolone.

This article is a comprehensive guide on Andarine based on all of the current scientific literature and the analysis of thousands of anecdotal reports and experiences.

You will learn:

  • What is Andarine
  • Benefits
  • Side Effects
  • Proper Use & Dosing
  • PCT

What is Andarine?

Andarine (also known as S4, Androxolutamide, and GTx-007) was one of the first SARMs ever developed alongside Ostarine. It was originally developed for the treatment of muscle wasting conditions and osteoporosis just like Ostarine.

Andarine is an incredible compound overall, it is effective at reducing prostate size in rats with Benign Prostatic Hyperplasia. Unfortunately, S-4 never reached Phase I Clinical Trials so we have no scientific data on the effects it has on humans. Fortunately, it has been used recreationally by so many users, that we have a lot of anecdotal information to go by.


Muscle Gain

The anabolic effects of Andarine are very similar to Ostarine. Both will build a similar amount of muscle at their recommended dosages.

It will still retain and even increase muscle mass while on a caloric deficit like all the other SARMs.

Strength and Endurance

Andarine will improve your strength and overall performance in the gym significantly.

Even though it is pretty hard to compare it with other SARMs in terms of boosting strength, users often report better strength gains than on Ostarine.

Fat Loss

Andarine will not make you lose more fat. But if taking it while on a caloric deficit it will make you look a lot leaner and tighter than you actually are. Not to mention that it’s great at maintaining muscle and even increasing it while on a caloric deficit.

Bones and Joints

Andarine will increase your bone density and make your bones stronger. And while it does not have the same joint-healing abilities as Ostarine, it does not usually cause dry joints despite being a dry compound.


Andarine speeds up recovery and reduces soreness, so you should expect to be ready for action again much sooner after a workout than if you were still natural.

Cosmetic Benefits

The cosmetic benefits of Andarine are probably the biggest reason why so many users still take it. Andarine is known for giving a very dry, hard, vascular look, making it a very good choice for events like shows or photoshoots.

Side Effects

Testosterone Suppression

Andarine, like all SARMs, will suppress your natural testosterone production.

However Andarine is one of the least suppressive SARMs, therefore this is a minor adverse effect that is easily reversible and manageable.  Again, the level of suppression is comparable to that of Ostarine.

The symptoms of a reduction in testosterone can be:

  • Decreased libido
  • Weaker erections
  • Lethargy
  • Lack of motivation
  • Irritability
  • Testicular pain
  • Testicular atrophy

Fortunately, most users only have a couple of these (if any) and only for a short period of time, usually near the end of the cycle and for the first week or two after the cycle has ended.

NOTE: All SARMs decrease your SHBG, and Andarine is no different. In the first few weeks of your cycle, your free testosterone levels will rise as a result of this, which will improve your motivation, libido, and overall well-being.

These effects end when the suppression of total testosterone kicks in and cancels out the increase in free testosterone.


Andarine will cause dyslipidemia, and just like all SARMs, it will cause a significant decrease in your HDL and an increase in your LDL.

This side-effect doesn’t make you feel any different, so you won’t know the extent of the damage done to your lipid panel unless you do bloodwork at the end of your cycle.

Vision and Light Sensitivity

This is the iconic Andarine side-effect that turns most people away from it. A very bizarre side-effect that will give a yellowish/green tint to your eyes. 

It will also make it more difficult to adapt to changes in brightness and limit your ability to see in low-light situations.

Fortunately, these issues fade away once the cycle is over. Most users report that they are simple to adjust to and do not significantly impair vision during the cycle

Important: Most users only experience this side effect on doses of 50 mg/day or higher.

Liver Toxicity

There is no scientific evidence showing that Andarine is hepatoxic, nevertheless, elevated liver enzymes are not that uncommon after a cycle. 

Other Side Effects

The side-effects mentioned up until now will impact the majority of users however, the following will only affect a very tiny minority.

  • Gynecomastia: Breast tissue grown in males. An extremely rare side-effect caused by an imbalance of hormones, testosterone and estrogen. Men who developed gynecomastia in their teens are at a greater risk of developing it again if they take S-4
  • Hair shedding: This is an extremely rare side-effect, the rarest of this whole list. Thankfully it’s always temporary and fully reversible.
  • Insomnia: Another rare side-effect that some people get, it is entirely unpredictable. But can be dealt with and managed very easily.

Dosing, Optimal Usage & Cycling

Dosing Information:

Fortunately, Andarine is very simple to run as it’s very mild in terms of side effects. 

Cycle Length

The optimal cycle length for Andarine is 8 weeks. This is because of a troublesome protein called myostatin (MSTN). In short, myostatin is your body’s natural mechanism to regulate the amount of muscle you add.

When you take SARMs, it causes myostatin levels to rise as your body responds to the excess muscle. Which by the 8th week becomes enough to ruin your progress and drive you into a plateau.


The optimal dosage for Andarine is between 25 mg/day and 75 mg/day. Exceeding 75 mg/day will not bring a proportionate increase in muscle to the increase in side effects that you will experience. Aka – diminishing returns.

This generally applies to all SARMs. Less is more.

Post Cycle Therapy (PCT)

Andarine is mild when it comes to the suppression of natural testosterone. Of course, this varies from person to person, but most people will be able to get away without doing a PCT at low doses.

The only way to know if you need a PCT for sure is through bloodwork. Always have a SERM at hand ready to deploy, no matter how confident you are in your natural ability to recover.

How to determine if you need to PCT after Andarine:


Symptoms of Suppression


Total Testosterone & LH within reference range (even if close to bottom)



Total Testosterone & LH within reference range (even if close to bottom)



Total Testosterone & LH below reference range



Can't Do Bloodwork (For Whatever Reason)



Can't Do Bloodwork (For Whatever Reason)



How to PCT after Andarine:

For a SARM like Andarine using any of the SERMs will work as a PCT. Though Tamoxifen, Enclomiphene and Toremifene have been shown to deliver the best results.
























The table above has the dosing information regarding every SERM. Simply pick one, and stick with it for three weeks starting the day after you finish your Andarine cycle.

If you can get your hands on Enclomiphene then definitely run it. It can potentially increase your testosterone levels slightly beyond the reference range and help you maintain and even build more muscle during your PCT.


Andarine is one of the most unusual and at the same time incredible PEDs out there. It’s perfect for athletes and lifters that want to add a bit of extra muscle, or preserve muscle during a cut, whilst ensuring a smooth recovery and lasting gains after their cycle.

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