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As a ghrelin receptor agonist, MK677 works by attaching itself to the ghrelin receptor in the brain and signaling the secretion of GH and IGF-1. It doesn’t have androgenic properties, nor does it increase serum testosterone by lowering SHBG, as SARMs do. Despite this, you can find countless cases of users who developed gyno after their MK677 cycle.
MK677 has the potential to cause gyno by increasing prolactin, though very, very rare. The prolactin increase it causes is not strong enough to cause gyno by itself. Those who are naturally prone to gyno, and have an imbalance between testosterone and estrogen already are more likely to develop it on MK677.
Keep on reading for a more detailed answer. This article is based on the latest academic data, the analysis of thousands of anecdotal reports online, as well as my own experiments on myself and over 500 lifetime clients in conditions deemed as controlled as possible.
One of the side effects of MK 677 is a slight increase in prolactin. High prolactin levels can lead to the development of gyno in some men.
The extent of the increase in prolactin that MK677 causes is not by itself enough to cause gynecomastia.
But, if you are someone who has had gynecomastia in the past or during puberty, you are at a greater risk of developing it again if you take MK 677.
If you want to be 100% on the safe side of things, get your prolactin levels checked by doing bloodwork. If your baseline prolactin levels are over the reference range, I would suggest taking measures to bring them down before taking MK 677.
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To prevent this side effect, take 100mg of Vitamin B6 (P5P form) before bed during your MK677 cycle. Do this even if you’re not prone to gyno as this dose of P5P doesn’t have side effects and will improve your health and sleep.
Again, it is extremely unlikely if you are not prone to it, but, If you feel any early symptoms of gyno like nipple pain or swelling, you can also take:
Prolactin-induced gyno from MK677 is rare and if you follow these instructions it will not happen to you.
MK677 is cheap to manufacture, but despite that, it’s still not that uncommon to get an underdosed bottle or a completely different chemical that actually can cause gyno among other equally bad or worse side effects.
I’m certain that 99%, if not all of the anecdotal reports of MK677 causing gyno involve a tainted and fake product.
High-quality MK677 is not hard to come by and opting to buy from a shady merchant that offers suspiciously cheaper prices can bite you back.
Even though fake chemicals are not as common as they once were, only shop from reputable sources that have a good reputation in the community. My recommended sources are:
All ship worldwide, but shipping times may vary from the US.
They ship worldwide but shipping times may vary.
CamoChem (Liquid)If you’re someone with a family history of gynecomastia or someone who developed gyno during puberty, you have a risk of redeveloping it if you take any kind of drug that alters your hormonal balance.
To be safe, have Raloxifene at your disposal whenever taking things that might provoke the development of gyno (or just skip the PED train and stay natty forever).
All ship worldwide though shipping times may vary, all of the companies are based in the US.
SwissChems
AminoAsylumIf you have gyno MK677 can make it worse by increasing prolactin. Before taking any kind of gyno-provoking PED get rid of your existing gynecomastia first.
Stacking multiple SARMs by itself can lead to gyno, and MK677 can top that off by increasing prolactin.
NOTE: If you’re someone who has had gyno before during puberty, you are at a much higher risk of redeveloping it again if you take SARMs.
A lot of users have the misconception that stacking 2 SARMs of the same kind, will lead them to get better results.
When you take two SARMs of the same kind (ex, RAD 140 and LGD 4033) they end up fighting over the same androgen receptors. And the SARM with the higher binding affinity always wins – leaving the other one in your bloodstream, giving you little additional benefit while exacerbating the side effects of both compounds.
Always stack a SARM with a research chemical or PED that works through a different pathway to achieve synergy between the compounds like:
Also keep in mind that SARMs like YK11 and S23 are known to cause androgenic side effects, which could lead to the development of gyno if one is prone to it.
Real, high quality MK677 is very unlikely to cause gyno unless you’re someone who has had it during puberty, or are taking MK677 with other AAS and SARMs. To be safe get your prolactin levels tested, have Raloxifene at hand, and get high quality MK 677.
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