Many users compare RAD 140 and YK11 to see which one is “better” for their specific goals. The issue here is that they work completely differently and are incomparable if the context of the question is “Which one should I use over the other?”.
RAD 140 and YK 11 are not comparable for one main reason:
They work through mechanisms of action and build muscle via different muscle-building pathways.
In this article, you’ll learn their exact differences across their benefits and side effects, and more importantly, their effective use based on their mechanisms of action. This information is based on the latest scientific literature and the analysis of thousands of anecdotal cases and experiences online.
The main difference between YK11 and RAD 140, and all other SARMs for that matter, is its mechanism of action. If the context of the question is which one should I take over the other, then knowing what we’ll talk about next will completely disband that question, as they are used completely differently.
YK11 works completely differently than the rest of the SARMs. It is a steroidal SARM of the 19-Nor family (Nandrolone) and a theorized myostatin inhibitor:
YK11 builds muscle via the myostatin pathway.
Myostatin is a natural limiter to the amount of muscle you can build. It is a protein that our body developed over thousands of years of evolution because an overly muscular frame is not ideal for survival.
Research suggests that YK11 has a dual action mechanism, both as a SARM and as a myostatin inhibitor. It attaches to androgen receptors like SARMs and AAS but also increases the expression of follistatin. Follistatin is a protein that binds to and neutralizes myostatin, effectively blocking its inhibitory effects on muscle growth.
RAD 140 works by attaching to androgen receptors in your skeletal muscle tissue and bones. It shares the same mechanism of action as the rest of the selective androgen receptor modulators.
Because of their core differences, RAD 140 and YK11 are simply not comparable. YK11 is (almost) always used in addition to another SARM as a wingman compound to inhibit myostatin and boost the muscle-building properties of the other primary compound.
Even if you were to use it by itself, it would be hard to estimate exactly how much muscle it would build since it is almost never used alone, and we have very little empirical data to go by.
The rest of the article will cover the remaining properties of both compounds, namely the side effects, benefits, and how to properly use each one.
The graphs below illustrate the side effects and benefits associated with each SARM. Based on the previous points made, the info on YK11 is concluded by looking at the limited anecdotal cases that ran it solo.
Note that these points are based on thousands of anecdotal reports, but your results may vary. YK11 has always been classified as one of the most suppressive SARMs, but some people argue it’s not that suppressive when used on its own.
RAD 140 can be used for bulking, cutting, and recomp cycles alike. However, it should never be stacked with other SARMs that have the same mechanism of action.
This goes into my theory for stacking SARMs, which I’ve come to believe by analyzing thousands of anecdotal cases. It goes as follows:
When you stack similar SARMs, they end up fighting for the same receptors, and the one with a higher binding affinity wins, making the other SARM useless.
In most cases where users stacked similar SARMs like RAD 140 and LGD 4033, they experienced only a small increase in benefits compared to when they took just one or the other. But they experienced all of the side effects associated with both SARMs.
YK11 is best used in addition to other SARMs. That way, both compounds work in a synergistic fashion by accumulating muscle growth through different mechanisms instead of against each other. It is the single best compound to stack with other SARMs as it creates synergy.
Because of this, RAD 140 and YK11 are very often taken together.
RAD 140 and YK11 cannot be compared because they work through different muscle-building pathways. YK11 builds muscle by inhibiting myostatin, while RAD 140 does so by attaching to androgen receptors.
Another reason why they are incomparable is that YK11 is almost always used with another SARM in order to amplify it by inhibiting myostatin. Therefore, anecdotal reports of YK11 solo runs are rare, and we don’t have enough data to make any conclusions or estimations.
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