MK 677 is one of the most synergistic research chemicals to stack alongside other PEDs. Which is one of the reasons it’s become one of the most popular PEDs in existence.
But what does that mean?
Each PED stimulates muscle growth via a muscle-building pathway. Androgen-based PEDs like SARMs and AAS, stimulate muscle growth by attaching to androgen receptors. MK 677 stimulates muscle growth by attaching to ghrelin receptors, which signal the release of GH and IGF-1, some of the most anabolic hormones in the body.
So if you want to maximize results, and put health first, you would be wise to combine different PEDs in such a way that they support each other by working through different pathways.
/*! elementor - v3.11.5 - 14-03-2023 */The increase in GH and IGF-1 makes MK 677 extremely effective at muscle building, general recovery, and even fat loss through lipolysis. Paired with the mildness of its side effects, you get a truly exceptional compound for synergistic stacking.
Of course, it does come with its own risks, which I go into detail about in the comprehensive MK 677 guide.
MK 677, contrary to common belief, is an exceptional compound to use in both cutting and bulking stacks.
So what can you combine MK 677 with?
Depending on whether you’re planning a cutting or bulking cycle, your options will differ. Needless to say, versatile SARMs like RAD 140 and Ostarine will be great for any game plan. Keep on reading for the details.
P.S. I’ve taken the time to make a stacking spreadsheet based on the concept of synergy. It neatly shows you what you can combine.
When it comes to bulking MK 677 can be taken with most of the SARMs for very decent results. Experienced users typically stack it with:
These compounds are generally very effective at putting on muscle, so combining MK 677 with them makes a lot of sense. But what about LGD 4033?
While LGD 4033 is the considered the best bulking SARM, stacking it with MK 677 for a bulking cycle is not a good idea unless you’re keeping the doses low and being strict with diet and supplementation. This is because both compounds cause water retention which can become excessive and cause problems.
MK677 is rarely used for cutting because users fear that the increase in hunger might sabotage their diet. This can be easily prevented by taking MK677 a few hours before bed.
But what many also don’t know is that MK677 is exceptional at accumulating fat loss through nutrient partitioning and lipolysis. This is also the same mechanism of action behind the popular fat loss peptide known as Frag 176-191.
Lipolysis on MK677 can only happen when insulin levels are low, which is best achieved through fasting. To leverage this property, and at the same time avoid hunger, take MK677 3 hours after your last meal, before bed followed by 3-4 hours of fasting the following morning.
For cutting, MK 677 works best with mildly and moderately strong SARMs like:
Additionally other PEDs that synergistically act on different mechanisms that aid in fat loss can also be utilized. These include peroxisome proliferator-activated receptor (PPAR) agonists like:
and Rev-ErbA agonists like:
P.S. Make sure the MK 677 you’re getting is legit. These are my recommended sources:
| WEEK | LGD 4033 | MK677 | TAMOXIFEN |
|---|---|---|---|
| 1 | 5mg/day | 15 mg/day | |
| 2 | 5mg/day | 15 mg/day | |
| 3 | 5mg/day | 15 mg/day | |
| 4 | 5mg/day | 15 mg/day | |
| 5 | 5mg/day | 15 mg/day | |
| 6 | 5mg/day | 15 mg/day | |
| 7 | 5mg/day | 15 mg/day | |
| 8 | 5mg/day | 15 mg/day | |
| 15 mg/day | 20mg/day | ||
| 15 mg/day | 20mg/day | ||
| 15 mg/day | 20mg/day | ||
| 15 mg/day | 10mg/day |
Suitable For:
LGD 4033 and MK 677 make an incredible combo for beginners who want to explode in size while keeping side effects to a minimum.
Depending on the doses you decide to take, you might experience excess water retention which can be dealt with by lowering your carbohydrate and sodium intake, supplementing with potassium, and drinking more water.
On LGD 4033 and MK 677 you can expect to gain a few pounds within days and look much fuller and bigger. As you go through the cycle you will experience steady gains week by week.
To run this stack properly you need to know your exact daily calorie maintenance and use it with a small surplus so that you don’t end up looking fat and puffy. If done right you can expect to make gains of up to 10 – 15lbs, 2-4 of which are typically water weight.
LGD 4033 might require a PCT. Though some users will be able to get away without one. Regardless, having a SERM on hand is a good idea. In the example I’ve listed Tamoxifen, but any SERM could work.
Trusted LGD-4033 sources: US, EU
Highest possible discounts with codes: POP10 & POP20
| WEEK | RAD 140 | MK677 | TAMOXIFEN |
|---|---|---|---|
| 1 | 10mg/day | 10mg/day | |
| 2 | 10mg/day | 10mg/day | |
| 3 | 10mg/day | 10mg/day | |
| 4 | 10mg/day | 10mg/day | |
| 5 | 15mg/day | 10mg/day | |
| 6 | 15mg/day | 10mg/day | |
| 7 | 15mg/day | 10mg/day | |
| 8 | 15mg/day | 10mg/day | |
| 10mg/day | 20mg/day | ||
| 10mg/day | 20mg/day | ||
| 10mg/day | 20mg/day | ||
| 10mg/day | 10mg/day |
Suitable For:
MK677 and RAD 140 are an incredible combo for bulking for those that want to stay lean and vascular during their bulk while getting stronger from session to session.
RAD 140 will make you a lot stronger, much more than LGD 4033 would. It’s also dry, meaning that it will not retain any water and make you look puffy. MK 677 will enhance muscle building, aid in recovery, and allow for a greater caloric intake by increasing hunger.
RAD 140 may require a PCT, so have a SERM ready to go in case you need it. If you run this stack as a cutting cycle, you are more likely to need a PCT, as a caloric deficit will exacerbate testosterone suppression
After the cycle is over you could continue using MK677 for the duration of the PCT in order to aid with recovery and help you keep the gains from your cycle, and even make new gains.
If you want to take this cycle one step further you can increase the dose of RAD 140 to 15mg/day at the 4-week mark, but only if you tolerated 10 mg/day well.
If you do decide to go this route, adding a test base in the form of a SARM + SERM protocol to manage testosterone suppression would be very beneficial. It would also enable you to skip PCT as your testosterone levels would stay in the upper half of the reference range.
Trusted RAD 140 sources: US, EU
Highest possible discounts with codes: “POP10” & “POP20”
| WEEK | OSTARINE | MK677 | TAMOXIFEN (OPTIONAL) |
|---|---|---|---|
| 1 | 20mg/day | 15mg/day | |
| 2 | 20mg/day | 15mg/day | |
| 3 | 20mg/day | 15mg/day | |
| 4 | 20mg/day | 15mg/day | |
| 5 | 20mg/day | 15mg/day | |
| 6 | 20mg/day | 15mg/day | |
| 7 | 20mg/day | 15mg/day | |
| 8 | 20mg/day | 15mg/day | |
| 9 | 15mg/day | 20mg/day | |
| 10 | 15mg/day | 20mg/day | |
| 11 | 15mg/day | 20mg/day | |
| 12 | 15mg/day | 10mg/day |
Suitable For:
Ostarine and MK 677 make for a very effective yet mild bulking combination. Not as strong as the RAD 140 and LGD 4033 stacks, but, much safer and less suppressive.
You can expect to make noticeable gains and steady progress, but nothing crazy. Not everyone will need to PCT after Ostarine but having a SERM like Tamoxifen at hand is always recommended. If you run this stack as a cutting cycle, you are more likely to need a PCT, as a caloric deficit will exacerbate testosterone suppression
After the cycle is over you can choose to continue using MK677 for four more weeks to help with recovery and maintenance.
Trusted MK-2866 sources: US, EU
Highest possible discounts with codes: POP10 & POP20
Suitable For:
SR9009 and MK677 are an effective non-suppressive cutting stack. You will lose a considerable amount of fat running these compounds together, while staying side effect free, healthy, and functional.
Cardarine (GW501516) can also be used as it has a longer half life, though the shorter half life of SR9009 should not be a problem considering the cancer risk from GW501516.
MK 677 is a very versatile compound that can be synergistically stacked with a variety of PEDs in almost any setting to achieve any objective: whether it be cutting, bulking, or recomp.
Its properties and mildness in terms of side effects open many doors and even make it a great supplementary compound in any cycle.
A document I originally made for my clients. A neat map to the sphere of PEDs, and supplements.
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