One of the most serious side-effects of Trenbolone that doesn’t get much attention is the effect it has on our brain.
According to animal (rat) studies, Trenbolone is able to cross the blood-brain barrier and induce apoptosis of primary hippocampal neurons and increases the concentration of a protein known as A-Beta-42.
In other words, Trenbolone kills neurons in the hippocampus, which is the region of the brain that controls both short-term and long-term memory. Furthermore, high AB42 concentrations have been linked to Alzheimer’s disease.
This is incredibly concerning, because it means that repeated Trenbolone use could seriously affect one’s memory, promote neurodegeneration and increase the chances of one developing dementia or Alzheimer’s later in life.
What’s also concerning is that in this study, not even Testosterone and estradiol were able to protect the brain from Trenbolone, meaning that the theory that keeping estradiol levels slightly high on Trenbolone to prevent brain damage is NOT valid.
But is all hope lost? Is it possible to use avoid or at least mitigate this terrible side-effect?
The truth is we don’t know. We could theorize that supplementing with neuroprotective nootropics that stimulate memory by increasing the expression of neurotransmitters like glutamate and acetylcholine in the hippocampus MAY counteract the neurotoxicity of Trenbolone, but this is just a theory that has never been studied.
My nootropic of choice would be Oxiracetam, which has also been shown to decrease the expression of the protein A-Beta-42 that Trenbolone increases.
In my opinion, athletes who want (or rather NEED) to use Trenbolone should consider supplementing with nootropics like Oxiracetam + Alpha-GPC and limit Trenbolone use as much as possible to prevent long-term brain damage.
Everything you would ever want or need to know about SARMs, and how to properly use, maximize, and recover from them.
The SARMs Wiki is the culmination of 7 years worth of knowledge coming from independent experimentation with myself and hundreds of my clients, probably thousands of hours of research, going through every study, and the online reports of thousands of SARMs and PED users.
If you're ready to spend 150$+ on SARM cycles, why not do it right from the very start and save yourself the troubles of dealing with the nuances and complications of PED use?
The Peptide Wiki is an all-in-one guide that will give you a deep understanding of how each peptide works and how you can use them correctly and find the perfect one (or stack) to reach your goals (16 Total Most Popular Peptides Covered).
Not only will you learn how these peptides work in your body, but you will also learn how to prevent their potential side-effects, and how to reconstitute, dose, and store use them correctly (super easy to mess this up).
If you're going to spend hundreds of $ on Peptides, you might as well do them right.
I wrote this ebook/document with one goal in mind: To share the info that has helped dozens of my clients completely turn their sex lives around.
Everything that I have to say on how to do bloodwork as an enhanced (or to be enhanced!) lifter.
Which markers to test, how to read the results, how often to get each marker tested, and more.
A document I originally made for my clients. A neat map to the sphere of PEDs and supplements.
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A special gift to all my email subscribers. The PED Dictionary is a DOC designed to help you navigate the world of enhanced bodybuilding. A game changer for beginners that want to learn more but don't know where to start, and a must-have handbook for even the most advanced enhanced researchers.
