BPC-157 & TB-500 Protocols for Treating Any Injury

BPC 157 and TB 500 are two peptides famous for their ability to treat a wide range of injuries, including tendon or ligament ruptures, partial and very rarely even complete tears as well as bone fractures, burns, and wounds.

Both BPC 157 and TB 500 naturally occur in humans and animals. They play a variety of roles in the body, ranging from anti-inflammation and healing to gastric health. Athletes primarily use BPC 157 and TB 500 for their ability to rapidly heal an injury through a process known as “angiogenesis”.

This article is a comprehensive guide on using BPC 157 and TB 500 for treating injuries. It is based on the latest academic data, the analysis of thousands of anecdotal reports and experiences online, as well as my own experiments with myself and over 500 lifetime clients./*! elementor - v3.16.0 - 09-10-2023 */<br /> .elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}

Dosage Protocols

BPC 157 and TB 500 don’t need to be cycled. If trying to heal something or recover from an injury, you simply use them until you are healed.

You can dose BPC 157 and TB 500 simultaneously or separately. I recommend dosing them separately as they have different half-lives and will need to be injected at different times for optimal results.

If you didn’t already know this, I’ve included a detailed breakdown of both compounds further down the article.

BPC 157 Protocol

BPC 157 can be injected or taken orally. Some prefer to take it orally for ease of use, but it’s much less effective and you’d have to take large amounts to get decent results. This is not only less effective for threating the injury, but also expensive to sustain.

Injectable administration is preferable for treating injuries.

Injecting BPC 157 subcutaneously, close to the injured area is the most effective way to use it as BPC 157 has incredible localized effects but mediocre systemic effects.

The ideal injectable dosage range for BPC 157 is:

• 250mcg to 500mcg per day

You can inject either once or twice a day. I advise for more frequent injections, but once a day will also work.

Use BPC 157 as long as needed to heal your injury. There is no need to cycle it.

TB 500 Protocol

The exact half-life of TB 500 is still unclear. We only know that it is considerably longer than BPC 157. So daily injections are not required. It is recommended to do every other day injections, but every 3 days is also doable. This is the protocol most clinics follow.

Unlike BPC 157, TB 500 has incredible systemic effects. Meaning that it doesn’t matter where you inject it.

The recommended dosage range for TB 500 is:

• 1 to 2mg every other day

If you’re trying to heal an injury, use TB 500 for as long as necessary.

Otherwise, many users get great results. When taking it for other purposes, many users benefit from cycling it for up to 8 weeks at a time.

How to Use Them Together

The best way to use BPC 157 and TB 500 together is to simply dose them separately, as they have different half-lives.

Note: That doesn’t mean that you can’t inject them together. It’s as simple as mixing in TB 500 with your daily BPC 157 injections, but every other day.

IMPORTANT: BPC 157 and TB 500 come in powdered form. Before you can inject them you must reconstitute these peptides in bacteriostatic water! This article features a how-to on injections, keep reading.

Mechanisms of Action

BPC-157 and TB-500 share similar mechanisms of action, namely, for the purpose of treating injuries, they induce what is known as angiogenesis.

Angiogenesis is a biological process that involves the growth of new blood vessels from pre-existing ones. It is essential for wound healing and tissue repair, and whenever you sustain an injury your body heals it via this process.

Both BPC 157 and TB 500 promote and induce angiogenesis helping you heal injuries faster./*! elementor - v3.16.0 - 09-10-2023 */<br /> .elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:"";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}

What is BPC 157

BPC 157 is derived from a naturally occurring sequence of amino acids found in gastric juices. When injected BPC 157 induces angiogenesis locally. It also has properties that greatly aid cognitive, cardiovascular and digestive health.

BPC 157 Benefits

• Healing of Wounds, Burns, Bruises, Scars, and even Mosquito Bites (proven in pre-clinical studies and confirmed by empirical data) [1]
• Healing of Bones – effectiveness is comparable to bone marrow graft treatment. [2]
• Healing of Tendons – pre-clinical studies proved that BPC 157 heals tendons almost completely (even in rats that would have never recovered without it). Empirical data also confirms this with hundreds upon hundreds of reports of users that used BPC 157 to heal injured tendons even after years of pain. [2]
• Healing of Muscles – pre-clinical studies proved BPC 157 to be effective at healing cut or torn muscles in rats. There are also many anecdotal cases of bodybuilders who used it to speed up recovery after an injury. [3]
• Neuroprotection – multiple pre-clinical studies proved the effectiveness of BPC 157 at protecting the brain in rats. It can heal nerve damage and significantly reduce the aftermath of brain injuries. [4]
• Improved Digestive Health – since it’s found in the gut, it makes sense that BPC 157 would improve gut health. Pre-clinical studies have shown BPC 157 to heal ulcers and fistulas while improving gut flora. Empirical evidence has also shown that it effectively treats Inflammatory Bowel Disease. [5]

BPC 157 Side Effects

• Cancer Growth – before you freak out and discard BPC 157 completely, let me clarify. BPC 157 induces angiogenesis (healing property), which is the formation of new blood vessels. This trait is phenomenal, but with people that are already suffering from cancer, it can speed up the rate at which it grows. [7]
• Injection-Related Side Effects – many people don’t know how to inject peptides correctly, which can lead to scar tissue build-up, irritation and other annoying side effects (there’s a section on proper administration further down).

What is TB 500

TB 500 is a synthetic form of a naturally occurring peptide Thysomin Beta-4 (TB4) which can be found in many tissues in both humans and animals. TB4 has many roles, but its main ones are tissue regeneration and anti-inflammation.

One of the most studied roles of thymosin beta-4 is in wound healing. It promotes cell migration, angiogenesis (formation of new blood vessels), and downregulates inflammatory responses, thereby accelerating tissue repair.

TB 500 Benefits

• Healing of Burns & Wounds – TB4 is proven effective at healing wounds, cuts and burns (even more rapidly than BPC 157) by promoting the formation of new blood vessels (angiogenesis). It’s also effective at preventing scars and fibrosis. [8]
• Healing of Bones & Ligaments – pre-clinical studies have proven TB 500’s effectiveness at speeding up the healing process of bone fractures and ligament injuries. Anecdotal reports of athletes who have deployed TB 500 to heal such injuries further confirm that these findings apply to humans as well. [9]
• Neuroprotection – pre-clinical studies show that TB 500 might be effective at attenuating and preventing brain damage after injuries. [11]
• Healing of Muscles – TB-500 is frequently said to enhance muscular development, strength, and endurance. It can undoubtedly repair muscle injuries and encourage the regeneration of muscle cells following exercise-induced stress, but there isn’t any conclusive pre-clinical, clinical, or anecdotal evidence to support its ability to significantly enhance muscle growth and strength. To date there is only one academic paper backing these effects. [10]
• Fights Hyperglycemia – TB 500 has been shown to improve insulin sensitivity. [12]
• Cardioprotective – there is scientific data to support that TB 500 has cardioprotective traits, as it prevents fibrosis and cardiac ischemia. [12]

TB 500 Side Effects​

• Cancer Risk – some studies have found increased levels of TB4 in cancer cells, which has led some scientists to believe that it plays a role in cancer development, and others that its part of the body’s response to cancer. What we do know for sure is that TB4 promotes angiogenesis like BPC 157 so it can also lead to growing existing tumors. [13]
• Injection-Related Side Effects – many people don’t know how to correctly inject peptides which often leads to skin irritation, scar tissue build and other annoying effects.

In pathological conditions such as cancer, angiogenesis is often dysregulated, leading to the formation of abnormal blood vessels that support tumor growth and metastasis. So taking TB 500 if you have cancer is a very bad idea to say the least.

How to Inject TB 500 & BPC 157

Subcutaneous belly fat injections are the easiest and least painful for TB 500. BPC 157 has amazing localized effects, but mediocre systematic effects. So the optimal way to use it is to inject it subcutaneously close to the injured area.

To do the injections you will need:

1. Alcohol wipes
2. Syringe
3. Brand new insulin needle or any needle with the following measurements:
   • 28 to 31G
   • 8 to 12 mm in length.

How to do the subcutaneous injections:

1. Wash your hands
2. Get a vial of TB 500 or BPC 157 and clean the rubber stopper with an alcohol wipe
3. Insert the needle into the vial
4. Turn the vial upside down, with the needle inserted, and slowly pull the desired amount while making sure no air bubbles or air gaps form
5. Remove the needle, and get rid of any bubbles by tilting it vertically and pushing them out and lightly tapping the syringe
6. Rub the injection site with alcohol wipes
7. Pinch your skin between your thumb and your index and middle fingers, lifting it up pulling away from the underlying muscle
8. Insert the needle at a 90-degree angle, or if you have a very thin layer of fat at a 45-degree angle
9. Inject your TB 500 and/or BPC 157 slowly, 10-30 seconds
10. Withdrawal the needle
11. Massage the skin with an alcohol wipe for a few moments
12. Congratulations, you made it!

Conclusion

When taken together BPC 157 and TB 500 create a synergy unlike any other, and are capable of healing injured tendons, ligaments, and even bones. 

They have been extensively used and recommended by thousands of professional athletes, bodybuilders, and even everyday people that were lucky enough to stumble upon them.

There are thousands of anecdotal cases online showcasing their potential to heal injuries, which further supports the scientific data we have on them.

Most importantly, they are side effect free (unless you already have cancer). If you are over-concerned, you can opt to skip TB 500 and just do BPC 157. But, in my opinion, you should be alright taking both.

Good luck, and I wish you a speedy recovery! 

References:

BPC-157

1. Healing of Wounds and Burns

• The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
• Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
• Influence of a novel pentadecapeptide, BPC 157, on healing of a transected latissimus dorsi muscle in the chicken
• Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat
• A novel pentadecapeptide, BPC 157, influences the healing of a transected quadriceps muscle in the rat

2. Healing of Bones and Tendons

• The influence of a novel pentadecapeptide, BPC 157, on bone healing in rabbits
• Pentadecapeptide BPC 157 positively affects both muscle healing and bone healing in the rabbit model
• Therapeutic effect of pentadecapeptide BPC 157 on tendon lesions in the rat
• Beneficial effect of BPC 157 on tendon healing in the rat

3. Healing of Muscles

• Pentadecapeptide BPC 157 accelerates muscle healing in injured rats
• BPC 157 enhances the healing of muscle injuries in the rat
• The effect of BPC 157 on muscle healing in a rat model

4. Neuroprotection

• Pentadecapeptide BPC 157 and its role in accelerating musculoskeletal soft tissue healing
• BPC 157’s role in brain injury recovery
• Neuroprotective effects of BPC 157 in a rat model of brain injury
• BPC 157 and its potential in central nervous system disorders

5. Improved Digestive Health

• The effect of BPC 157 on gastrointestinal tract disorders
• BPC 157 as a potential new therapy for inflammatory bowel disease
• BPC 157 and its effect on ulcerative colitis
• The influence of BPC 157 on Crohn’s disease
• BPC 157 and its healing effect on inflammatory bowel diseases

6. Other Benefits

• The effect of BPC 157 on systemic corticosteroid-impaired muscle healing
• The effect of pentadecapeptide BPC 157 on direct and indirect tendon-to-bone healing
• BPC 157 and its influence on the healing of segmental bone defect in rabbits
• BPC 157 and its effect on the healing of skin wounds in diabetic rats

7. Cancer Growth

• The effect of BPC 157 on tumor growth and metastasis

TB-500 (Thymosin Beta-4)

8. Healing of Wounds and Burns

• Thymosin Beta-4 accelerates wound healing in mice
• The role of Thymosin Beta-4 in skin repair and regeneration
• Thymosin Beta-4 and its effect on wound healing in diabetic rats
• The effect of Thymosin Beta-4 on burn wound healing
• Thymosin Beta-4 and its role in enhancing skin graft survival
• Thymosin Beta-4 and its potential in the treatment of skin wounds

9. Healing of Bones and Tendons

• Thymosin Beta-4 and its effect on tendon healing
• The role of Thymosin Beta-4 in bone regeneration
• Thymosin Beta-4 and its influence on fracture healing

10. Muscle Growth

• Thymosin Beta-4 and its role in muscle regeneration

11. Neuroprotection

• Neuroprotective effects of Thymosin Beta-4 in a rat model of stroke
• Thymosin Beta-4 and its potential in neurodegenerative diseases

12. Other Benefits

• Thymosin Beta-4 and its role in cardiac repair
• The effect of Thymosin Beta-4 on heart regeneration
• Thymosin Beta-4 and its influence on cardiac healing after myocardial infarction
• The role of Thymosin Beta-4 in cardiac protection
• Thymosin Beta-4 and its effect on heart disease
• Thymosin Beta-4 in the treatment of heart failure

13. Cancer Risk

• Thymosin Beta-4 and its association with cancer risk
• The potential role of Thymosin Beta-4 in cancer development
• Thymosin Beta-4 and its influence on tumor growth
• The effect of Thymosin Beta-4 on cancer cell proliferation
• Thymosin Beta-4 and its role in cancer metastasis
• The potential of Thymosin Beta-4 in cancer therapy
• Thymosin Beta-4 and its effect on tumor angiogenesis

A document I originally made for my clients. A neat map to the sphere of PEDs, and supplements.

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