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What is PT-141: Benefits & Side Effects + Proper Use Explained

PT-141 Improve sexual function for men & women

PT 141, also known as Bremelanotide and Vyleesi, is a very effective and increasingly popular peptide for enhancing both female and male sexual desire and performance.

Though it was developed for women and is approved by the FDA for treating low sexual desire in women, it also improves erectile function in men.

In this article you will learn everything there is to know about PT 141 based on the latest academic literature data and mass analysis of thousands of anecdotal reports and experiences online.

What is PT 141?

PT 141 is a synthetic analogue of a naturally occurring peptide hormone called a-MSH, which is a metabolite of Melanotan-II. And as such, it has some of the same potential side effects.

PT 141 provides the sexual enhancement benefits of Melanotan-II without the increase in melanogenesis. It’s approved by the FDA and is widely considered as a cutting-edge safe and effective drug for the treatment of a condition that has never had an easy solution: sexual dysfunction in women.


Even though PT 141 is originally intended for women, it also has incredible benefits for men. Generally, this is what it does in terms of benefits:

  • Increased Sexual Desire in Women
  • Increased Sexual Function in Men

Sexual Desire In Women [1][A]

PT-141 or Bremelanotide is proven to safely and effectively increase sexual desire in women, which also includes postmenopausal women. There have been numerous clinical trials, and the data is clear.

Those who participated in the clinical trials also experienced an improvement in sexual satisfaction and orgasms.

Anecdotal data from women who used PT-141 and shared their experiences online further confirm these findings.

Sexual Function In Men [2][A]

Although it has not been researched as extensively as in women, the data regarding PT-141 for men is still very promising and there is a lot more anecdotal information from men.

PT-141 will improve erectile function significantly, even in men who do not respond to PDE5 inhibitors like Viagra.

According to most of the anecdotal reports from men, PT-141, unlike Viagra or Cialis, causes erections that are hard to manage. Meaning that they occur even in the absence of stimulation.

Though the half-life of this peptide is short and is almost always used strategically (before sex). So you shouldn’t worry about having unwanted spontaneous erections.

Other Benefits [A]

As a Melatonan II metabolite, it would be safe to assume that PT 141 has the potential to carry over the fat loss, anti-aging, and anti-inflammatory benefits of Melatonan II.

Side Effects

All of these side effects have been observed throughout the clinical trials, you can find the exact sources at the end of this article. They are not specific to any administration method, and apply to both PT-141 nasal sprays and injections, with the exclusion of injection-related side effects.

Headaches & Nausea [3][A]

Headaches and nausea were fairly common throughout the clinical trials, and are reported anecdotally. The easiest way to prevent or mitigate headaches from PT 141 is to start with a small dose and work your way up.

Flushing [3][A]

Facial flushing from PT 141 is common, but only lasts for a few minutes and is completely harmless.

Darkened Skin [A]

There have been anecdotal reports of users that experienced darkened skin after using PT 141 daily for months on end. Not surprising as this peptide has close ties with Melatonan II.

This effect is temporary, harmless, and naturally reversible.

Injection Related Side Effects [A]

Many people don’t know how to properly inject peptides. Improperly injecting PT-141 can lead to some annoying, though inconsequential side effects like skin irritation, and scar tissue build up. 

Use & Dosing Protocol

PT 141 is very easy to use, and the same dosages apply to men and women. There are two methods of administration:

  • Intranasal Sprays
  • Injections

Both are nasal sprays and injections are effective, though injections require a smaller dose for the same effect, making them more cost-effective.

Dosage for Injections






If Well Tolerated



Inject 125mcg subcutaneously into your lower belly fat 30-45 minutes before having sexual intercourse. If you find that you tolerate this dose well, and don’t experience any of the side effects like a headache or nausea, then you can increase the dose to 250mcg.

There is no need to cycle this peptide, you can simply use it whenever you need it.

Keep in mind that to do the injections you will have to purchase the PT-141 in powdered form and reconstitute it in BAC or sterile water yourself.

P.S. Make sure the PT-141 you’re getting is legit. These are my recommended sources for the highest-quality powder out there:

Nasal Spray Dosage

For intranasal administration follow the same instructions as injections, but with twice the dose.






If Well Tolerated



P.S. Make sure the PT-141 you’re getting is legit. This is my recommended source for the highest-quality spray out there:


PT 141 is an incredible drug that can literally change how you feel about yourself, your relationships, and with that your life. Remember, always start with a small dose and work your way up to see how well you tolerate a PT 141 (and any drug for that matter).

PT-141 kicks in at 30-45 minutes after administration, regardless of injected subcutaneously or taken through a nasal spray.

PT-141 does not make you tan as Melatonan II does. It does not cause melanogenesis.

The effects of PT-141 last for 3 hours after administration.

PT-141 has a half-life of 3 hours, so it would take a total of 6 hours before all of the active substance leaves your system.

PT-141 can sit in the fridge for a few months without spoiling or loosing effectiveness.

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